Luminescent iridium(<scp>iii</scp>) dipyrrinato complexes: synthesis, X-ray structures, and DFT and photocytotoxicity studies of glycosylated derivatives
Neha Manav, Mohsin Y. Lone, Md Kausar Raza, Jaydeepsinh Chavda, Shigeki Mori, Iti Gupta
Abstract
values were between 17 and 25 μM after light exposure, and confocal microscopy revealed significant localization of the glycosylated Ir(III) complexes in the endoplasmic reticulum (ER) of cancer cells. The neutral Ir(III) dipyrrinato complexes are promising tracking agents for cellular imaging in the biological window and for photodynamic therapy (PDT) applications.
Topics & Concepts
IridiumSinglet oxygenLuminescenceChemistryX-rayPhotochemistryApoptosisCombinatorial chemistryStereochemistryCrystallographyOxygenMaterials scienceBiochemistryOrganic chemistryCatalysisOptoelectronicsPhysicsQuantum mechanicsLuminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionPorphyrin and Phthalocyanine Chemistry