MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-κB pathway
Danhua Yao, Zhiyuan Zhou, Pengfei Wang, Lei Zheng, Yuhua Huang, Yantao Duan, Bin Liu, Yousheng Li
Abstract
, miR-125-5p overexpression significantly improved the severity of colitis, including DAI score, colon length, tissue damage, apoptosis, and inflammatory response, in the mice in the UC group. In addition, miR-125-5p up-regulation significantly reduced the expression of IL-6 R in the UC mice, and reduced the expression levels of JAK1, STAT3 and p65 phosphorylation. MiR-125-5p targeting IL-6 R regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-κB pathway.
Topics & Concepts
ApoptosisBiologyUlcerative colitisIn vivoColitisSTAT3Signal transductionCancer researchInflammationInflammatory bowel diseaseMacrophageImmunologyMolecular biologyIn vitroCell biologyPathologyMedicineBiochemistryBiotechnologyDiseaseMicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseases