PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
Isabel Syndikus, Clare Cruickshank, John Staffurth, Alison Tree, Ann Henry, Olivia Naismith, Helen Mayles, Nicola Snelson, Shama Hassan, Stephanie Brown, Núria Porta, Clare Griffin, Emma Hall
Abstract
•PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are most likely to benefit.•Functional MRI imaging is used to select patients for different types of dose escalation.•HDR brachytherapy or focal dose escalation with IMRT are used as options.•Training and support is provided to reduce variations of contouring and radiotherapy planning.•The trial is recruiting patients in 38 radiotherapy centres through the UK.
Topics & Concepts
MedicineContouringRadiation therapyProstate cancerProstateBrachytherapyPelvisRadiologyOncologyInternal medicineCancerEngineering drawingEngineeringProstate Cancer Diagnosis and TreatmentMRI in cancer diagnosisProstate Cancer Treatment and Research