Polysarcosine functionalised cationic polyesters efficiently deliver self-amplifying mRNA
Hulya Bayraktutan, Rafał J. Kopiasz, Amr Elsherbeny, Magda Martinez-Espuga, Nurcan Gümüş, Umut Can Öz, Krunal Polra, Paul F. McKay, Robin J. Shattock, Paloma Ordóñez‐Morán, Álvaro Mata, Cameron Alexander, Pratik Gurnani
Abstract
In this work we demonstrate the endcapping of a poly(beta-amino ester) of polysarcosine, a widely established PEG-alternative, and show its ability as a non-viral vector for self-amplifying mRNA.
Topics & Concepts
Cationic polymerizationPolyesterMessenger RNAChemistryPEG ratioAmino acidPolymerPolymer chemistryBiophysicsBiochemistryOrganic chemistryBiologyGeneFinanceEconomicsRNA Interference and Gene DeliveryBiopolymer Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques