A pH/ATP-responsive nanomedicine via disrupting multipath homeostasis of ferroptosis for enhanced cancer therapy
Xiangyu Meng, Zhuoxuan Lu, Liming Zhang, Zhifei Wang
Topics & Concepts
GPX4ChemistryLipid peroxidationReactive oxygen speciesCancer cellApoptosisProgrammed cell deathGlutathione peroxidasePhospholipid-hydroperoxide glutathione peroxidaseGlutathioneAdenosine triphosphateBiochemistryTumor microenvironmentCancer researchCell biologyAntioxidantCancerBiologyEnzymeMedicineInternal medicineTumor cellsFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsCancer, Lipids, and Metabolism