Copper-Catalyzed Chloro-Arylsulfonylation of Styrene Derivatives via the Insertion of Sulfur Dioxide
Yue Li, Lin Shen, Mi Zhou, Baojian Xiong, Xuemei Zhang, Zhong Lian
Abstract
A copper-catalyzed four-component chloro-arylsulfonylation of styrene derivatives with aryldiazonium tetrafluoroborates, lithium chloride, and ex-situ generated sulfur dioxide (from SOgen) is presented. This sulfonylation features good functional group compatibility, mild reaction conditions, excellent regioselectivity, and good yields. The robustness and potential of this method have also been successfully demonstrated by a gram-scale reaction. Based on experimental study, a radical-involved mechanism is proposed for the transformation.
Topics & Concepts
ChemistryRegioselectivityStyreneCatalysisCopperSulfur dioxideSulfurFunctional groupChlorideOrganic chemistryCombinatorial chemistryCopolymerPolymerSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods