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Elemental Sulfur-Promoted Aerobic Dehydrogenative Aromatization of Cyclohexanones with Amines

Zhen Wang, Li Cheng, Huawen Huang, Guo‐Jun Deng

2020The Journal of Organic Chemistry27 citationsDOI

Abstract

An elemental sulfur-promoted aerobic dehydrogenation system for the access to N,N′-dialkyl-o-phenylenediamines and N-substituted 2-naphthylamines is reported herein. Readily available cyclohexanones and amines (especially alkylamines) are transformed smoothly to target products. Aromatic amines can be achieved from all aliphatic reagents under aerobic metal-free reaction conditions. Control reactions show that the combinational use of elemental sulfur and molecular oxygen is exceptionally essential for this dehydrogenative aromatizaiton.

Topics & Concepts

DehydrogenationSulfurAromatizationChemistryReagentElemental analysisMolecular oxygenOrganic chemistryOxygenOxidative phosphorylationCombinatorial chemistryCatalysisBiochemistryCatalytic C–H Functionalization MethodsChemical Synthesis and ReactionsSulfur-Based Synthesis Techniques
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