“Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya
Jane M. Simoni, Kristin Beima‐Sofie, George Wanje, Zahra H. Mohamed, Kenneth Tapia, R. Scott McClelland, Rodney J. Y. Ho, Ann C. Collier, Susan M. Graham
Abstract
BACKGROUND: Long-acting injectable (LAI) antiretroviral therapy (ART) may offer persons living with HIV (PLWH) an attractive alternative to pill-based treatment options, yet acceptability data remain scant, especially in sub-Saharan Africa. METHODS: We conducted 6 focus group discussions with PLWH, including key stake holder groups, and analyzed data with content analysis. RESULTS: Initial reactions to the idea of LAI-ART were often positive. The primary advantages voiced were potential to facilitate improved adherence and alleviate the burden of daily pill-taking while avoiding inadvertent disclosure and HIV stigma. Potential side effects were a particular concern of the women. Most participants preferred clinic-based administration over self-injections at home due to concerns about safety, privacy, and potential need for refrigeration. CONCLUSIONS: LAI-ART may be acceptable in Kenya, provided injections are infrequent and delivered in a clinic setting. However, HIV stigma, fear of potential side effects, and limited clinical capacity would need to be addressed.