Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Ahmed M. Sayed, Amira R. Khattab, Asmaa M. AboulMagd, Hossam M. Hassan, Mostafa E. Rateb, Hala Zaid, Usama Ramadan Abdelmohsen
Abstract
acetylglucopetunidin (31), isoxanthohumol (32) and ellagic acid (33), which are widely available in many edible fruits, obey both Lipinski's and Veber's rules of drug-likeness and thus possess high degrees of predicted bioavailability. These natural products are suggested as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics in the near future.
Topics & Concepts
Context (archaeology)DrugDrug discoveryNatural productEllagic acidCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AntiprotozoalChemistryPharmacologyComputational biologyBiologyMedicineDiseaseBiochemistryIn vitroInfectious disease (medical specialty)PolyphenolAntioxidantPathologyPaleontologyComputational Drug Discovery MethodsSynthesis and biological activityBioactive Compounds and Antitumor Agents