Visible-Light-Promoted Trifluoromethylthiolation and Trifluoromethylselenolation of 1,4-Dihydropyridines
Xiwen Shan, Xiaoxing Wang, Enxue Chen, Juyan Liu, Kui Lu, Xia Zhao
Abstract
We report a metal-free trifluoromethylthiolation and trifluoromethylselenolation of 1,4-dihydropyridines with S-(trifluoromethyl) 4-methylbenzenesulfonothioate and Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate under visible light irradiation. This transformation was tolerated with a wide range of functional groups and provided an alternative and green strategy for the synthesis of trifluoromethylthioesters and trifluoromethylselenoesters.
Topics & Concepts
ChemistryTrifluoromethylVisible spectrumTransformation (genetics)IrradiationPhotochemistryCombinatorial chemistryOrganic chemistryOpticsGeneAlkylPhysicsNuclear physicsBiochemistryFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesInorganic Fluorides and Related Compounds