A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells
Gang Zhang, Shan Li, Feng Wang, Amanda C. Jones, Alexander F. G. Goldberg, Benjamin Lin, Scott C. Virgil, Brian M. Stoltz, Raymond J. Deshaies, Tsui‐Fen Chou
Topics & Concepts
ChemistryBiochemistryPyrimidineATPaseIC50Covalent bondHigh-throughput screeningEnzymeStereochemistryIn vitroOrganic chemistryATP Synthase and ATPases ResearchHeat shock proteins researchEndoplasmic Reticulum Stress and Disease