An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn <i>6485f</i> Encoding <i>bla</i> <sub>IMP-45</sub> and <i>bla</i> <sub>AFM-1</sub> and a Second Plasmid with Two Copies of <i>bla</i> <sub>KPC-2</sub>
Yinfei Fang, Nanfei Wang, Zhaoxia Wu, Yijun Zhu, Yongjun Ma, Yue Li, Heng Cai, Piaopiao Zhang, Sebastián Leptihn, Yunsong Yu, Xiaoting Hua, Yuexing Tu
Abstract
The ST463 clone is an emerging high-risk sequence type that is spreading with bla KPC-2 -containing plasmids. The core bla KPC-2 genetic platform is IS Kpn27 -b la KPC-2 -IS Kpn6 in almost all samples, and the adjacent region beyond the core platform varies by IS 26 -mediated inversion or duplication events, amplifying the bla KPC-2 gene copies.
Topics & Concepts
Transposable elementPlasmidBiologyGeneticsIntegronInsertion sequenceGeneGene duplicationPseudomonas aeruginosaGenomeBacteriaAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingInfections and bacterial resistance