Quantitative detection of microRNA-21 <i>in vivo</i> using <i>in situ</i> assembled photoacoustic and SERS nanoprobes
Liting Zheng, Qingqing Li, Ying Wu, Lichao Su, Wei Du, Jibin Song, Lanlan Chen, Huanghao Yang
Abstract
A miR-21-activated self-assembled AuNNP@AuNP core–satellite was developed to quantify the absolute concentration of miR-21 via enhanced photoacoustic and ratiometric SERS signals in vivo for the first time.
Topics & Concepts
Photoacoustic imaging in biomedicineIn situIn vivomicroRNANanotechnologyChemistryMaterials scienceBiochemistryBiologyPhysicsOrganic chemistryOpticsBiotechnologyGeneAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and ApplicationsExtracellular vesicles in disease