Redox-Sensitive Hyaluronic Acid Polymer Prodrug Nanoparticles for Enhancing Intracellular Drug Self-Delivery and Targeted Cancer Therapy
Beibei Lü, Fan Xiao, Zhenyuan Wang, Binshen Wang, Zuchen Pan, Weiwei Zhao, Zhenye Zhu, Jiaheng Zhang
Abstract
pharmacokinetics and biodistribution studies showed that the prodrug had a longer circulation time in BALB/c mice and higher accumulation in 4T1 tumors. Interestingly, the prodrug could effectively treat tumors with few side effects. These results showed that the DOX prodrug micelles developed in this study may have great potential in targeted therapy.
Topics & Concepts
ProdrugNanocarriersMicelleConjugateDrug deliveryHyaluronic acidBiodistributionDoxorubicinChemistryPharmacologyDrugTargeted drug deliveryIn vivoBiophysicsBiochemistryIn vitroChemotherapyAqueous solutionMedicineOrganic chemistryBiologyBiotechnologyMathematical analysisMathematicsAnatomySurgeryNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery