Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor
Rita Fuerst, Jun Yong Choi, Anna M. Knapinska, Michael D. Cameron, Claudia Ruiz, Amber L. Delmas, Mark S. Sundrud, Gregg Fields, William Roush
Topics & Concepts
ChemistryOxetaneChelationSelectivityMoietyStereochemistryLead compoundDocking (animal)EnzymeCombinatorial chemistryIn vitroBiochemistryOrganic chemistryNursingCatalysisMedicineProtease and Inhibitor MechanismsInflammatory mediators and NSAID effects