Chronic hyperglycemia induces tau hyperphosphorylation by downregulating OGT-involved O-GlcNAcylation in vivo and in vitro
Rong Huang, Sai Tian, Haoqiang Zhang, Wenwen Zhu, Shaohua Wang
Topics & Concepts
HyperphosphorylationGlycationMorris water navigation taskDiabetes mellitusAdvanced glycation end-productPhosphorylationInternal medicineEndocrinologyIn vivoPathogenesisDownregulation and upregulationHippocampusStreptozotocinChemistryGene knockdownMedicineBiologyBiochemistryApoptosisGeneBiotechnologyGlycosylation and Glycoproteins ResearchAdvanced Glycation End Products researchProteoglycans and glycosaminoglycans research