Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase
Ericka Kirkpatrick Roubidoux, Meagan McMahon, Juan Manuel Carreño, Christina Capuano, Kaijun Jiang, Viviana Simon, Harm van Bakel, Patrick C. Wilson, Florian Krammer
Abstract
The influenza virus neuraminidase is an emerging target for universal influenza virus vaccines. However, in contrast to influenza virus hemagglutinin, we know little about antibody epitopes and antigenic sites on the neuraminidase. Characterizing and defining these sites is aiding vaccine development and helping to understand antigenic drift of NA.
Topics & Concepts
EpitopeNeuraminidaseVirologyMonoclonal antibodyAntigenic driftVirusHemagglutinin (influenza)BiologyAntibodyOriginal antigenic sinInfluenza A virusH5N1 genetic structureAntigenAntigenic shiftImmunologyMedicineInfectious disease (medical specialty)PathologyDiseaseCoronavirus disease 2019 (COVID-19)Influenza Virus Research StudiesRespiratory viral infections researchRNA and protein synthesis mechanisms