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An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone

Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julien Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu‐Dong Kong, Boštjan Kobe, Yi‐Lei Zhao, Mehdi Mobli, Xudong Qu

2025Nature Chemistry11 citationsDOI

Topics & Concepts

ChemistryAcetalTricyclicDiels–Alder reactionDual (grammatical number)Organic chemistryOxygenUnit (ring theory)Combinatorial chemistryStereochemistryCatalysisMathematicsArtLiteratureMathematics educationMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry MethodsCarbohydrate Chemistry and Synthesis
An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone | Litcius