The Current Landscape of Immune Checkpoint Inhibitor Immunotherapy for Primary and Metastatic Brain Tumors
Paolo Alimonti, L. Nicolas Gonzalez Castro
Abstract
Antibodies against immune checkpoint inhibitors (ICIs) have revolutionized the treatment of multiple aggressive malignancies, including melanoma and non-small cell lung cancer. ICIs for the treatment of primary and metastatic brain tumors have been used with varying degrees of success. Here, we discuss the available evidence for the use of ICIs in the treatment of primary and metastatic brain tumors, highlighting challenges and opportunities for furthering this type of cancer immunotherapy in neuro-oncology.
Topics & Concepts
ImmunotherapyMedicineMelanomaMetastatic melanomaCancerImmune checkpointImmune systemOncologyLung cancerCancer researchBrain metastasisInternal medicineImmunologyMetastasisGlioma Diagnosis and TreatmentBrain Metastases and TreatmentCancer Immunotherapy and Biomarkers