Antifibrotic effect of AD-1 on lipopolysaccharide-mediated fibroblast injury in L929 cells and bleomycin-induced pulmonary fibrosis in mice
Tao Li, Yu Chen, Yuan Li, Gang Chen, Yuqing Zhao, Guangyue Su
Abstract
, and the underlying mechanism may be related to the decrease in ECM deposition and inflammation, the enhancement of antioxidant capacity, and the mediation of lung cell apoptosis and the TGF-β1/TIMP-1/α-SMA signaling pathway, which provide a theoretical basis for the rehabilitation treatment of PF.
Topics & Concepts
BleomycinPulmonary fibrosisFibroblastLipopolysaccharidePulmonary InjuryFibrosisMedicineCancer researchImmunologyChemistryPharmacologyPathologyInternal medicineIn vitroChemotherapyBiochemistryInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPeptidase Inhibition and AnalysisPneumonia and Respiratory Infections