Sputum Metabolites Associated with Nontuberculous Mycobacterial Infection in Cystic Fibrosis
Paul A. Breen, Madsen Zimbric, Kristopher Opron, Lindsay J. Caverly
Abstract
Host risk factors for nontuberculous mycobacterial (NTM) infection in people with cystic fibrosis (CF) are largely unclear. The goal of this study was to help identify potential host and bacterial community risk factors for NTM infection in people with CF, using microbiome and metabolome data from CF sputum samples. The data obtained in this study identified several metabolic profile differences in sputum associated with NTM infection in CF, including 2-methylcitrate/homocitrate and selected ceramides. These findings represent potential risk factors and therapeutic targets for preventing and/or treating NTM infections in people with CF.
Topics & Concepts
SputumMetabolomeNontuberculous mycobacteriaMetabolomicsBiologyCystic fibrosisMicrobiomeMicrobiologyImmunologyInternal medicineMedicineTuberculosisMycobacteriumPathologyBioinformaticsMycobacterium research and diagnosisGut microbiota and healthCystic Fibrosis Research Advances