ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
Guangyan Miao, Hongyu Zhao, Yan Li, Ming-Ming Ji, Yong Chen, Yi Shi, Yuhai Bi, Pei‐Hui Wang, Hong Zhang
Topics & Concepts
AutophagyBiologyCell biologyEndosomeAutophagosomeLipid bilayer fusionVacuolar protein sortingLysosomeViral replicationVirusVirologyBiochemistryEnzymeIntracellularApoptosisAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismMosquito-borne diseases and control