Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis
Qian Hua, Baoming Mi, Fei Xu, Jun Wen, Li Zhao, Jianjun Liu, Gang Huang
Abstract
: Together, these data provided evidence that AC020978 conferred an aggressive phenotype to NSCLC and was a poor prognosticator. Targeting AC020978 might be an effective therapeutic strategy for NSCLC.
Topics & Concepts
PKM2Chromatin immunoprecipitationImmunoprecipitationCell growthBiologyCancer researchDownregulation and upregulationGlycolysisPyruvate kinaseMolecular biologyChemistryCell biologyCell cultureGene expressionBiochemistryMetabolismGenePromoterGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCancer, Hypoxia, and Metabolism