Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones
Andrea H. Venable, Lauren E. Lee, Kyle Feola, John Santoyo, Tatyana Broomfield, Sarah C. Huen
Abstract
The mitochondrial enzyme hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) catalyzes the rate-limiting step of ketogenesis. Although the liver constitutively expresses HMGCS2 and is considered the main ketogenic organ, HMGCS2 is induced in the kidney during fasting, leading to the proposal that the kidney contributes to fasting ketosis. We showed kidney HMGCS2 does not contribute to circulating ketones during fasting and cannot compensate for hepatic ketogenic insufficiency.
Topics & Concepts
KidneyExpression (computer science)EndocrinologyInternal medicineBiologyMedicineComputer scienceProgramming languageDiet and metabolism studiesAdipose Tissue and MetabolismDiet, Metabolism, and Disease