Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation
Zhongyang Hong, Qingsong Tie, Lingling Zhang
Topics & Concepts
Beta adrenergic receptor kinaseG protein-coupled receptor kinaseProinflammatory cytokineInflammationSignal transductionKinaseRheumatoid arthritisImmune systemReceptorHypoxia (environmental)Cell biologyG protein-coupled receptorBiologyMedicineBioinformaticsImmunologyChemistryGeneticsOxygenOrganic chemistryCancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancerBiochemical and Molecular Research