Biocompatible iron(<scp>iii</scp>) carboxylate metal–organic frameworks as promising RNA nanocarriers
Tania Hidalgo, Marta Alonso‐Nocelo, Belén L. Bouzo, Sonia Reimóndez-Troitiño, Carmen Abuín, María de la Fuente, Patricia Horcajada
Abstract
Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.
Topics & Concepts
Biocompatible materialNanocarriersInternalizationNucleic acidRNAChemistryIn vitroNanotechnologyNanoparticleMaterials scienceBiochemistryCellGeneBiomedical engineeringMedicineRNA Interference and Gene DeliveryMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques