Impact of blood-brain barrier permeabilization induced by ultrasound associated to microbubbles on the brain delivery and kinetics of cetuximab: An immunoPET study using 89Zr-cetuximab
Vu Long Tran, Anthony Novell, Nicolas Tournier, Matthieu Gerstenmayer, Arnaud Schweitzer-Chaput, Claudia Mateos, Benoit Jégo, Alizée Bouleau, Hervé Nozach, Alexandra Winkeler, Bertrand Kühnast, Benoît Larrat, Charles Truillet
Topics & Concepts
MicrobubblesCetuximabBlood–brain barrierMonoclonal antibodyParenchymaEpidermal growth factor receptorCentral nervous systemMedicineCancer researchPathologyChemistryAntibodyUltrasoundImmunologyReceptorInternal medicineRadiologyUltrasound and Hyperthermia ApplicationsNanoparticle-Based Drug DeliveryPhotoacoustic and Ultrasonic Imaging