Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice
Jing Wen, Shangming Li, Chengyou Zheng, Fengjiao Wang, Yangwen Luo, Liangmiao Wu, Jie Cao, Baojian Guo, Pei Yu, Gaoxiao Zhang, Shupeng Li, Yewei Sun, Xifei Yang, Zaijun Zhang, Yuqiang Wang
Topics & Concepts
TetramethylpyrazineAmyotrophic lateral sclerosisSOD1Motor neuronPathogenesisSuperoxide dismutaseMedicineOxidative stressSOD2Muscle atrophyDenervationPharmacologySkeletal muscleNeuroscienceEndocrinologyInternal medicinePathologyBiologyDiseaseAlternative medicineAmyotrophic Lateral Sclerosis Researchbiodegradable polymer synthesis and propertiesParkinson's Disease Mechanisms and Treatments