CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease
Zhengwei Hu, Chengyuan Mao, Hui Wang, Zhongxian Zhang, Shuo Zhang, Haiyang Luo, Mibo Tang, Jing Yang, Yanpeng Yuan, Yanlin Wang, Yutao Liu, Liyuan Fan, Qimeng Zhang, Dabao Yao, Fen Liu, Jonathan C. Schisler, Changhe Shi, Yuming Xu
Abstract
/MPTP-induced PD models. Our experiments further revealed that CHIP maintains the integrity of mitochondria.
Topics & Concepts
MPTPParkinson's diseaseDiseaseChipNeuroscienceMedicineBiologyComputer scienceInternal medicineTelecommunicationsParkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyGenetics and Neurodevelopmental Disorders