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Synthesis, characterization, biological evaluation, DFT and molecular docking studies of (<i>Z</i>)-2-((2-bromo-4-chlorophenyl)imino)methyl)-4-chlorophenol and its Co(<scp>ii</scp>), Ni(<scp>ii</scp>), Cu(<scp>ii</scp>), and Zn(<scp>ii</scp>) complexes

Ibrahim Waziri, Hlonepho M. Masena, Tunde L. Yusuf, Louis‐Charl C. Coetzee, Adedapo S. Adeyinka, Alfred Muller

2023New Journal of Chemistry17 citationsDOIOpen Access PDF

Abstract

An equimolar reaction of 5-chlorosalicylaldehyde and 2-bromo-4-chloroaniline yielded the Schiff base ( Z )-2-((2-bromo-4-chlorophenyl)imino)methyl)-4-chlorophenol) (HL), which was used for complexation to Co 2+ , Ni 2+ , Cu 2+ , and Zn 2+ metal salts.

Topics & Concepts

ChemistrySchiff baseMetalMedicinal chemistryStereochemistryDocking (animal)Organic chemistryNursingMedicineMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity
Synthesis, characterization, biological evaluation, DFT and molecular docking studies of (<i>Z</i>)-2-((2-bromo-4-chlorophenyl)imino)methyl)-4-chlorophenol and its Co(<scp>ii</scp>), Ni(<scp>ii</scp>), Cu(<scp>ii</scp>), and Zn(<scp>ii</scp>) complexes | Litcius