Expression and function of human ribonuclease 4 in the kidney and urinary tract
Kristin Bender, Laura Schwartz, Ariel Cohen, Claudia Mosquera Vasquez, Matthew Murtha, Tad Eichler, Jason Thomas, Ashley R. Jackson, John David Spencer
Abstract
Ribonuclease 4 (RNase 4) is a newly identified host defense peptide in the human kidney and bladder. RNase 4 kills uropathogenic Escherichia coli (UPEC) and multidrug-resistant UPEC. RNase 4 prevents invasive UPEC infection and suppressed RNase 4 expression may be a risk factor for more severe or recurrent urinary tract infection.
Topics & Concepts
RNase PBiologyUrinary systemUrotheliumMicrobiologyEscherichia coliRibonucleaseKidneyMolecular biologyRNAGeneBiochemistryEndocrinologyUrinary Tract Infections ManagementEscherichia coli research studiesReproductive tract infections research