Dysbiotic Oral and Gut Viromes in Untreated and Treated Rheumatoid Arthritis Patients
Ruochun Guo, Shenghui Li, Yu Zhang, Yue Zhang, Guangyang Wang, Hayan Ullah, Yufang Ma, Qiulong Yan
Abstract
Our results demonstrated community variation among dental plaque, saliva, and fecal viromes. In oral and gut samples from untreated and treated RA patients, the perturbance of viral composition and the correlation network of microbes and RA-associated clinical indices might be involved in the pathogenicity of RA. The findings in this study expand the knowledge of the potential role of oral and gut viral communities in the development of RA and may contribute to research on correlations between viruses and other diseases.
Topics & Concepts
Human viromeBiologySalivaFecesLactococcus lactisMicrobiomeMetagenomicsFusobacterium nucleatumMicrobiologyGeneticsBacteriaLactic acidBiochemistryGenePorphyromonas gingivalisBacteriophages and microbial interactionsMycobacterium research and diagnosisHepatitis C virus research