Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function
Xuan Xu, Chu Chen, Wen-Jiang Lu, Yi-ling Su, Jiayu Shi, Yuchen Liu, Li Wang, Chen-Xi Xiao, Xiang Wu, Qi Lu
Abstract
BACKGROUND: ]m homeostasis was explored in depth. METHODS: uniporter (MCU)] were detected by Western blot. RESULTS: ]m overloading by increasing NCLX expression. CONCLUSIONS: ]m overload by increasing NCLX expression and thereby reducing ROS production and protecting the ΔΨm. At the same time, PQQ can increase PGC-1α and TFAM expression to regulate mitochondrial biogenesis. These factors can prevent mitochondrial dysfunction, thereby reducing cardiac damage caused by pressure overload and preventing the occurrence of CHF.
Topics & Concepts
Mitochondrial biogenesisTFAMMitochondrionReactive oxygen speciesAngiotensin IIMitochondrial ROSAtrial natriuretic peptidePyrroloquinoline quinoneInternal medicineEndocrinologyMedicineBiologyCell biologyBiochemistryReceptorCofactorEnzymeMicrobial metabolism and enzyme functionEicosanoids and Hypertension PharmacologyMitochondrial Function and Pathology