Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy
Mi Ra Noh, Hee‐Seong Jang, Fadi Salem, Fernando Ferrer, Jinu Kim, Babu J. Padanilam
Abstract
-450-dependent antihypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered renoprotective. We found that EET administration and/or soluble epoxide hydrolase inhibition significantly attenuates oxidative stress, renal cell death, inflammation, macrophage differentiation, and fibrogenesis following unilateral ureteral obstruction. Our findings provide a mechanistic understanding of how EETs prevent kidney fibrogenesis during obstructive nephropathy and suggest that EET treatment may be a potential therapeutic strategy to treat fibrotic diseases.
Topics & Concepts
Epoxide hydrolase 2PharmacologyKidneyChemistryOxidative stressEpoxyeicosatrienoic acidInflammationArachidonic acidProinflammatory cytokineFibrosisKidney diseaseMedicineEndocrinologyInternal medicineBiochemistryEnzymeEicosanoids and Hypertension PharmacologyLiver Disease and TransplantationNitric Oxide and Endothelin Effects