Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on quality by design (QbD)
Dong Han Won, Heejun Park, Eun‐Sol Ha, Hwan-Ho Kim, Sun Woo Jang, Min‐Soo Kim
Topics & Concepts
Quality by DesignBilayerCritical quality attributesTabletingDosage formMaterials scienceChemistryFixed-dose combinationPharmacologyBiomedical engineeringChromatographyParticle sizeMedicineMembraneBiochemistryPhysical chemistryDrug Solubulity and Delivery SystemsDiabetes Treatment and ManagementProtein purification and stability