Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma
Hollie A Clements, Tim Underwood, Russell Petty
Abstract
Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.
Topics & Concepts
MedicineNeoadjuvant therapyAdenocarcinomaIncidence (geometry)PerioperativeGastro-SurgeryCancerOncologyInternal medicineGeneral surgeryDiseaseRefluxBreast cancerOpticsPhysicsEsophageal Cancer Research and TreatmentGastric Cancer Management and OutcomesEsophageal and GI Pathology