(Salen)Titanium‐Catalyzed Asymmetric Hydrogen Atom Transfer for Epoxides Reduction
Zhongyun Xu, Jian Shen, Longfei Li, Wanjiao Chen, Shengxiao Li, Jie Jiang, Yongqiang Zhang
Abstract
Abstract Asymmetric hydrogen atom transfer (HAT) represents arguably one of the most straightforward access to the significant chiral tertiary carbon centers, however, remains a long‐standing challenge. Herein, the first example of catalytic coordination‐induced asymmetric HAT reaction has been developed relying on a sequential (salen)Ti III ‐initiated radical generation and (salen)Ti IV ‐controlled enantioselective HAT process. The reaction transforms easily accessible glycidic esters, thioesters and amides to synthetically valuable formal formaldehyde aldol adducts in an enantioconvergent manner, along with broad scope and highly regio‐ and enantioselectivities.