Counterion Tuning of Near-Infrared Organic Salts Dictates Phototoxicity to Inhibit Tumor Growth
Deanna Broadwater, Hyllana C. D. Medeiros, Matthew Bates, Amir Roshanzadeh, Shao Thing Teoh, Martin P. Ogrodzinski, Babak Borhan, Richard R. Lunt, Sophia Y. Lunt
Abstract
with minimal side effects. This work provides proof of concept that our counterion pairing platform can be used to generate improved cancer PSs that are selectively phototoxic to tumors and nontoxic to normal healthy tissues.
Topics & Concepts
PhototoxicityCounterionMaterials scienceInfraredPhotochemistryNanotechnologyIonOrganic chemistryOpticsChemistryBiochemistryPhysicsIn vitroNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging