Visible-Light-Induced Charge Transfer Enables C<sub>sp3</sub>–H Functionalization of Glycine Derivatives: Access to 1,3-Oxazolidines
Xiaorong Yang, Yin Zhu, Zhixiang Xie, Ying Li, Yuan Zhang
Abstract
A photoredox catalyst free, visible-light-induced aerobic oxidative [2 + 3] cycloaddition reaction between glycine derivatives and styrene oxides has been disclosed that provides an efficient approach for the rapid synthesis of 1,3-oxazolidines under mild conditions. This photoinduced process is enabled by the formation of an electron donor-acceptor complex between glycine derivatives and benzyl iodides.
Topics & Concepts
ChemistrySurface modificationGlycineCharge (physics)Combinatorial chemistryVisible spectrumPhotochemistryAmino acidOptoelectronicsBiochemistryQuantum mechanicsPhysicsPhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions