SMAD4-induced knockdown of the antisense long noncoding RNA BRE-AS contributes to granulosa cell apoptosis
Yao Wang, Xing Du, Jinbi Zhang, Yang Wang, Miaomiao Wang, Zengxiang Pan, Qifa Li
Abstract
-mediated GC apoptosis. In conclusion, we not only identified a novel AS-lncRNA related to the early apoptosis of GCs and initiation of follicular atresia but also described a novel regulatory pathway, SMAD4/BRE-AS/BRE, coordinating GC function and female fertility.
Topics & Concepts
Antisense RNAFollicular atresiaGene knockdownBiologyLong non-coding RNADownregulation and upregulationGeneApoptosisCell biologyRepressorRNAGeneticsGene expressionFollicular phaseOvarian follicleCancer-related molecular mechanisms researchRNA Research and SplicingCircular RNAs in diseases