C–H silylation and boronation enabled by alkyne insertion/vinyl to aryl 1,5-palladium migration
Zhendong Cheng, Weiwei Xu, Xuliang Tan, Zhengrui Zhou, Liwei Zhou, Yun Liang, Yuan Yang
Abstract
An alkyne insertion/vinyl to aryl 1,5-palladium migration strategy has been disclosed for the α-C–H silylation and boronation of a naphthalene ring, enabling the synthesis of silylated and boronated benzo[ f ]isoquinolines and benzo[ f ]isochromenes.
Topics & Concepts
ChemistrySilylationAlkynePalladiumArylPolymer chemistryMedicinal chemistryOrganic chemistryCatalysisAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry