Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma
Yasin Kaymaz, Cliff I. Oduor, Özkan Aydemir, Micah A. Luftig, Juliana A. Otieno, John Michael Ong’echa, Jeffrey A. Bailey, Ann M. Moormann
Abstract
Improved viral enrichment methods conclusively demonstrate EBV type 1 to be more prevalent in eBL patients than in geographically matched healthy controls, which previously underrepresented the prevalence of EBV type 2. Genome-wide association analysis between cases and controls identifies six eBL-associated nonsynonymous variants in EBNA1, EBNA2, BcLF1, and BARF1 genes. Analysis of population structure reveals that EBV type 2 exists as two genomic subgroups and was more commonly found in female than in male eBL patients.
Topics & Concepts
BiologyNonsynonymous substitutionGenomeLymphomaPopulationGeneticsVirologyVirusEpstein–Barr virusGeneImmunologyDemographySociologyViral-associated cancers and disordersLymphoma Diagnosis and TreatmentEosinophilic Disorders and Syndromes