Preparation of a novel regenerated silk fibroin-based hydrogel for extrusion bioprinting
Ni Chen, Xinbo Zhang, Jinyang Lyu, Guanglei Zhao, Kai Gu, Jun Xia, Zhong‐Chun Chen, Zhengzhong Shao
Abstract
Moreover, the microstructure of nanospheres stacked in these lyophilized 3D-bioprinted sponges was interesting to observe, which indicated the existence of microhydrogels and both "the reversible network" and "the irreversible network" in this HMWRSF-based pre-cured hydrogel. Like other HMWRSF materials fabricated in other ways, these 3D-bioprinted HMWRSF-based sponges exhibited good cytocompatibility for dental pulp mesenchymal stem cells. This work may inspire the design of functional HMWRSF-based materials by regulating the relationship between structure and properties.
Topics & Concepts
FibroinExtrusionAqueous solutionChemical engineeringSILKMaterials sciencePolymer scienceSelf-healing hydrogelsUreaPolymer chemistryChemistryComposite materialOrganic chemistryEngineeringSilk-based biomaterials and applications3D Printing in Biomedical ResearchBone Tissue Engineering Materials