Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies

Khaled R.A. Abdellatif, Eman K. A. Abdelall, Heba A.H. Elshemy, John N. Philoppes, Emad H. M. Hassanein, Nesma M. Kahk