Self-reporting heavy atom-free photodynamic therapy agents
G. Turkoglu, Gozde Kayadibi Koygun, Mediha Nur Zafer Yurt, Naime Demirok, Sündüs Erbaş-Çakmak
Abstract
Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.
Topics & Concepts
Photodynamic therapyMedicineChemistryOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials