Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction
Alejandro Chade, Alfonso Eirin
Abstract
Chronic kidney disease (CKD) is a progressive disorder in which more than 50% of deaths are attributed to cardiovascular disease. Using a swine model of CKD that develops left ventricular dysfunction (CKD-LVDD), we characterize the cardiac micro-RNA and transcriptomic profile, identifying dysregulated genes associated with cardiac remodeling and fatty acid metabolism that might be post-transcriptionally regulated early in the disease. These findings pinpointed pathological pathways that may open new avenues toward therapeutic research to reduce cardiovascular morbidity in CKD.
Topics & Concepts
Downregulation and upregulationKidney diseaseDiastoleInternal medicineTranscriptomeMedicineHeart failuremicroRNAVentricular remodelingCardiologyBiologyGene expressionBlood pressureGeneBiochemistryMicroRNA in disease regulationFuel Cells and Related MaterialsRNA modifications and cancer