Targeted Isolation of Cytotoxic Sesquiterpene Lactones from <i>Eupatorium fortunei</i> by the NMR Annotation Tool, SMART 2.0
Jiho Lee, Jinyoung Park, Juyeol Kim, Birang Jeong, Seong Yeon Choi, Hyeon Seok Jang, Heejung Yang
Abstract
values of 5.8 ± 0.1 μM against breast cancer cells, MCF-7. In the present study, the rapid annotation of the mixture of compounds in a fraction by the NMR-based machine learning tool helped the targeted isolation of bioactive compounds from natural products.
Topics & Concepts
SesquiterpeneCytotoxicityChemistryEupatoriumAsteraceaeTerpeneAnnotationBiologyIn vitroBiochemistryStereochemistryBotanyBioinformaticsSesquiterpenes and Asteraceae StudiesPlant Toxicity and Pharmacological PropertiesNatural product bioactivities and synthesis