Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)
Jayden C. McKinnon, Heloisa Milioli, Carley A. Purcell, Christine L. Chaffer, Bishoy Wadie, Theodore Alexandrov, Todd W. Mitchell, Shane R. Ellis
Abstract
, glutamate). This work provides one of the first reports of MALDI-2 applied to metabolite imaging and demonstrates the dramatic improvements in sensitivity and metabolite coverage it provides.
Topics & Concepts
MetaboliteChemistryLaserIonizationMatrix-assisted laser desorption/ionizationChromatographyBiochemistryPhysicsIonOpticsOrganic chemistryAdsorptionDesorptionMass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry StudiesMolecular Biology Techniques and Applications