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Mechanistic insights into cadmium-induced nephrotoxicity: NRF2-Driven HO-1 activation promotes ferroptosis via iron overload and oxidative stress in vitro

Tongwang Luo, Shengzhe Song, Shujie Wang, Sheng Jiang, Bin Zhou, Quanjiang Song, Lingjun Shen, Xiaodu Wang, Houhui Song, Chunyan Shao, Houhui Song, Chunyan Shao

2025Free Radical Biology and Medicine17 citationsDOI

Topics & Concepts

NephrotoxicityOxidative stressLipid peroxidationChemistryHMOX1FerritinKEAP1Cell biologyToxicityHemeReactive oxygen speciesTranscription factorHeme oxygenaseBiochemistryPharmacologyBiologyGeneOrganic chemistryEnzymeAir Quality and Health ImpactsHeme Oxygenase-1 and Carbon MonoxideFerroptosis and cancer prognosis
Mechanistic insights into cadmium-induced nephrotoxicity: NRF2-Driven HO-1 activation promotes ferroptosis via iron overload and oxidative stress in vitro | Litcius