Mitochondria-targeting nano therapy altering IDH2-mediated EZH2/EZH1 interaction as precise epigenetic regulation in glioblastoma
Babita Kaundal, Surajit Karmakar, Subhasree Roy Choudhury
Abstract
studies further displayed better tumor ablation in a GBM tumor-bearing nude mouse model. The present multimodal nanoformulation compromised the functional dependency of polycomb on mitochondrial IDH2 and established the mechanism of GBM inhibition.
Topics & Concepts
EZH2EpigeneticsMitochondrionCancer researchChromatin immunoprecipitationEpigenetic therapyCell biologyBiologyChemistryGene expressionDNA methylationBiochemistryPromoterGeneEpigenetics and DNA MethylationGlioma Diagnosis and TreatmentHistone Deacetylase Inhibitors Research